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Antibody repertoire: embracing diversity - PubMed
https://pubmed.ncbi.nlm.nih.gov/21795586/
The ability to increase the repertoire of antibodies induced by a vaccine may help to control variable pathogens that alter their exposed antigens to evade the immune system. Publication types Research Support, Non-U.S. Gov't Comment MeSH terms Adjuvants, Immunologic / therapeutic use* Animals Antibodies, Protozoan / immunology* Female Humans
Antibody Repertoire: Embracing Diversity
https://www.science.org/doi/10.1126/scitranslmed.3002694
However, the most important uses of the technique will almost certainly be (i) the investigation of the relationship between antibody repertoire diversity and protection from disease and (ii) the establishment of the role of different vaccine formulations in …
Antibody Repertoire: Embracing Diversity
https://www.science.org/doi/reader/10.1126/scitranslmed.3002694
at MF59 a ects antibody repertoire has now been demonstrated in both adults and children with an MF59-adjuvanted H1N1 vaccine (2). However, the characteristics of adjuvants that drive diversity in the anti- body repertoire are unknown and the tools to readily study the repertoire of antibody- producing B cells in vaccine recipients were
Antibody Repertoire: Embracing Diversity - ResearchGate
https://www.researchgate.net/publication/51527145_Antibody_Repertoire_Embracing_Diversity
the breadth of antibody response depends on the activation of naive germline b cell pool and subsequent somatic hypermutation in germinal centers, although the exact regulatory mechanism is …
Antibody repertoire: embracing diversity. — Immunology
https://www.immunology.ox.ac.uk/publications/167545
Antibody repertoire: embracing diversity. Pollard AJ., Hill AVS. In this Perspective, we discuss two papers that show that the breadth of the antibody response to vaccines could be manipulated by the use of particular vaccine adjuvants …
Antibody Repertoire: Embracing Diversity | Semantic …
https://www.semanticscholar.org/paper/Antibody-Repertoire%3A-Embracing-Diversity-Pollard-Hill/084120b88ca6dacb6ef0a4ece801d82a86b2ba3a
Two papers that show that the breadth of the antibody response to vaccines could be manipulated by the use of particular vaccine adjuvants that stimulate innate immune mechanisms are discussed. Adjuvanted formulations expand the vaccine-induced antibody repertoires against a virus and a parasite. In this Perspective, we discuss two papers that show that the breadth of …
Structural and genetic diversity in antibody repertoires …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039331/
(a) Unlike humans or mice, chickens use a gene conversion strategy to create a diverse antibody repertoire. A single VDJ event occurs on the heavy chain locus, followed by gene conversion using sequence homology from a number of 5′ pseudogenes (ψV H) which can be in rearranged form and donate diverse genetic fragments into the rearranged V region.
Structural and genetic diversity in antibody repertoires …
https://pubmed.ncbi.nlm.nih.gov/26188469/
Structural and genetic diversity in antibody repertoires from diverse species The antibody repertoire is the fundamental unit that enables development of antigen specific adaptive immune responses against pathogens. Different species have developed diverse genetic and structural strategies to create their respective antibody repertoires.
Case Study: Amplifying Antibody Diversity - AbCellera
https://www.abcellera.com/post/amplifying-antibody-diversity
With this approach, we can generate very large panels of antibodies with known properties and expand diversity around single cell data with RepSeq. The Challenge: A discovery program to identify an antibody against a validated human target, with 100% homology across mice, rats and humans. Accessing a diverse set of antibodies was a must.
Deep Mining of Human Antibody Repertoires: Concepts
https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202000451
nities in the deep mining of antibody repertoires are discussed. 1. Introduction Human humoral immune response to antigens is reliant upon the tremendous diversity of B cell receptors (BCR), the mem- brane-bound form of immunoglobulins (Ig). Key determinants of BCR diversity include 1) nearly random rearrangement of
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