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Breast Cancer Risk and Prevention: Genetic Testing
https://www.cancer.org/cancer/breast-cancer/risk-and-prevention/genetic-testing.html
BRCA1 and BRCA2 gene mutations. When it comes to breast cancer risk, the most important inherited gene changes are in the BRCA1 and BRCA2 genes. Women (and men) with one of these gene changes are said to have Hereditary Breast and Ovarian Cancer (HBOC) syndrome. Women with a BRCA gene change have a greatly increased risk of breast cancer, as well as an …
Genetic Testing for Hereditary Breast and Ovarian Cancer
https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/testing.htm
A known BRCA1, BRCA2, or other inherited mutation in your family. Genetic testing for hereditary breast and ovarian cancer looks for mutations in the BRCA1 and BRCA2 genes. Your doctor might suggest testing using a multigene panel, which looks for mutations in several genes at the same time, including BRCA1 and BRCA2.
Breast Cancer Genetics
https://www.nationalbreastcancer.org/breast-cancer-genetics/
Family history is one of the unavoidable genetic risk factors for developing breast cancer. Ongoing research is helping identify the genes that are responsible for this inherited increased risk. BRCA1 and BRCA2 gene mutations are currently the best-known and most discussed genetic risk factors, but new genetic links are being discovered regularly.
Genetic Testing for Breast Cancer
https://www.nationalbreastcancer.org/genetic-testing-for-breast-cancer
For some people, though, the chances of having a BRCA gene mutation are much higher. Genes are inherited, which is why knowing your family history is important when determining breast cancer risks. If one of your parents has a BRCA mutation, you have a 50% chance of inheriting the mutated gene. Odds can also vary depending on a person’s ethnicity.
Breast Cancer Gene Expression Tests | Tailor Your …
https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-gene-expression.html
Breast Cancer Gene Expression Tests. Gene expression tests are a form of personalized medicine - a way to learn more about your cancer and tailor your treatment. These tests are done on breast cancer cells after surgery or biopsy to look at the patterns of a number of different genes. This process or test is sometimes called gene expression profiling.
Tracing the origin of disseminated tumor cells in breast …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146893/
Tracing the origins of DTCs in the breast cancer phylogenetic trees. Copy number-based phylogenetic trees drawn up for patients MicMa003 ( a ), MicMa083 ( b ), and MicMa107 ( c ). Nodes in the trees correspond to (sub)clones and are color-coded based on their type as indicated (primary or lymph node, DTC, AU, or normal cell).
Tracing Breast Cancer’s History - Science
https://www.nationalgeographic.com/science/article/tracing-breast-cancers-history
A number of studies have shown that bilateral risk-reducing mastectomies (the official term) do indeed reduce the risk of breast cancer in women with the BRCA1 mutation. In a study published last...
Tracing the origin of disseminated tumor cells in breast …
https://pubmed.ncbi.nlm.nih.gov/27931250/
The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer. Results: We sequence the genomes of 63 single cells isolated from six non-metastatic breast cancer patients. By comparing the cells' DNA copy number aberration (CNA) landscapes …
Tracing the footprints of the breast cancer oncogene BRK …
https://pubmed.ncbi.nlm.nih.gov/25999240/
Tracing the footprints of the breast cancer oncogene BRK - Past till present Abstract Twenty years have passed since the non-receptor tyrosine kinase, Breast tumor kinase (BRK) was cloned. While BRK is evolutionarily related to the Src family kinases it forms its own distinct sub-family referred here to as the BRK family kinases.
Breastcancer.org - Breast Cancer Information and Support
https://www.breastcancer.org/symptoms/testing/genetic/neg_results
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