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Novel research using microbubbles, ultrasound against …
https://unclineberger.org/news/researchers-study-engineered-microbubbles-ultrasound-imaging-against-pancreatic-cancer/
March 6, 2020. By ckalnen. Pancreatic cancer puts up a strong defense against the immune system, preventing important cancer-fighting immune cells and immunotherapy treatments from reaching the tumor and doing their job. UNC Lineberger researchers are working on an innovative solution to this problem. UNC Lineberger’s Paul Dayton, PhD, and Yuliya …
Ultrasound Fights Cancer With Microbubbles
https://healthmanagement.org/c/healthmanagement/issuearticle/ultrasound-fights-cancer-with-microbubbles
By enhancing the ability of cells to absorb chemotherapeutics, an ultrasound technique has nearly doubled the median patient survival time from diagnosis …
Ultrasound and microbubbles flag malignant cancer in …
https://www.med.stanford.edu/news/all-news/2017/04/ultrasound-and-microbubbles-flag-malignant-cancer-in-humans.html
The microbubbles used in this study were designed to bind to a receptor called KDR found on the tumor blood vessels of cancer but not in healthy tissue. Noncancerous cells don’t have such a receptor. Under ultrasound …
Ultrasound- and Microbubble-Assisted Gemcitabine …
https://pubmed.ncbi.nlm.nih.gov/32046005/
Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles to increase the permeability of cell membranes. We assessed gemcitabine up …
Current status of targeted microbubbles in diagnostic …
https://pubmed.ncbi.nlm.nih.gov/33532585/
The use of molecularly targeted microbubbles that bind to neovascular targets can enhance the ultrasound signal specifically from malignant PDAC tissues. This review discusses the current state of diagnostic imaging modalities for pancreatic cancer and places a special focus on ultrasound targeted-microbubble technology together with its clinical translatability for PDAC …
Ultrasound with microbubbles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601836/
In summary microbubbles have expanded the role of US in the real-time characterisation of focal liver lesions based on specific enhancement patterns to differentiate benign and malignant lesions. Ultrasound contrast agents have significantly improved the sensitivity and specificity of ultrasound to rival that of CT and MR.
Clinical study of ultrasound and microbubbles for …
https://pubmed.ncbi.nlm.nih.gov/30510367/
Objective: To explore the safety of ultrasound and microbubbles for enhancing the chemotherapeutic sensitivity of malignant tumors in the digestive system in a clinical trial, as well as its efficacy. Methods: From October 2014 to June 2016, twelve patients volunteered to participate in this study. Eleven patients had hepatic metastases from tumors of the digestive …
Microbubbles: from cancer detection to theranostics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601112/
Microbubbles have proven to be useful as diagnostic agents for ultrasound[1,2]. However, they have the potential for a far wider range of uses, both in unmodified form (thus minimising regulatory barriers) and in new forms[3]. These future uses may be divided into diagnostic and therapeutic categories. Routine diagnostic uses of microbubbles relevant to …
Ultrasound And Microbubbles: An Unusual Approach To …
https://www.forbes.com/sites/helenalbert/2020/06/29/ultrasound-and-microbubbles-to-fight-cancer/
They injected microbubbles into breast tumors in mice, before exposing the mice to low frequency (250 kHz) ultrasound waves to ‘activate’ the bubbles to explode. This process killed 80% of the ...
Advances in low-frequency ultrasound combined with …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454312/
Microbubbles can reduce the threshold of the ultrasonic cavitation effect, enhance the cavitation effect, damage the vascular wall, activate endogenous or exogenous coagulation, induce large areas of capillary embolism, and block the nutritional supply of tumor cells, leading to tumor cell death (Yang et al., 2015b).
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