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In vivo Lineage-tracing Studies in a Cancer Stem Cell …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987099/
Lineage Tracing Reveals a Subset of Reserve Muscle …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597014/
To interrogate functional output of a heterogeneous set of cells requires techniques that can mark and track subsets of cells over time. Lineage tracing is the gold standard approach to determine the origin ... Expansion and transformation of radiotolerant cells may be one possible mechanism that leads to generation of cancer stem cells and ...
Lineage tracing: technology tool for exploring the …
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01941-y
Lineage tracing is the most widely used technique to track the migration, proliferation, and differentiation of specific cells in vivo. The currently available gene-targeting technologies have been developing for decades to study organogenesis, tissue injury repairing, and tumor progression by tracing the fates of individual cells.
Lineage tracing and targeting of IL17RB + tuft cell-like …
https://pubmed.ncbi.nlm.nih.gov/31182574/
Lineage tracing and targeting of IL17RB + tuft cell-like human colorectal cancer stem cells Cancer stem cell (CSC)-specific markers may be potential therapeutic targets. We previously identified that Dclk1, a tuft cell marker, marks tumor stem …
Lineage analysis of stem cells | StemBook
https://www.stembook.org/node/542
Unfortunately, lineage analysis has not yet been widely used to address the existence of cancer stem cells. 2.4.2. Transplantation Transplantation of cells can also create genetic mosaics. This has been carried out extensively in two …
Lineage tracing reveals Lgr5+ stem cell activity in mouse …
https://pubmed.ncbi.nlm.nih.gov/22855427/
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial.
Lineage tracing reveals metastatic dynamics: Cancer Cell
https://www.cell.com/cancer-cell/fulltext/S1535-6108(21)00326-3
Prospective lineage tracing increases tracing resolutions by ectopically introducing unique barcodes into cells prior to experimentation. However, such static barcodes cannot resolve subclonal relationships for cell populations that undergo constant evolution, such as during cancer metastasis.
Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse …
https://www.science.org/doi/10.1126/science.1224676
This strategy to document the behavior of stem cells is called lineage tracing. Although deletion of Apc in other cells of the intestinal epithelium does not lead to adenoma formation, we have shown that Apc-mutant Lgr5 + stem cells form progressively growing adenomas ( 4 ).
Frontiers | Stem Cells, Hematopoiesis and Lineage …
https://www.frontiersin.org/articles/10.3389/fcell.2022.903528/full
Assaying Hematopoietic Stem Cell Function: In Vivo Lineage Tracing While HSCs can regenerate an entire hematopoietic system following transplantation, it is now well recognized that this might reflect poorly of the dynamics and physiology of native hematopoiesis.
Lineage Tracing: Cell
https://www.cell.com/fulltext/S0092-8674(12)00003-7
Lineage tracing provides information about the number of progeny of the founder cell, their location, and their differentiation status. Used in classical developmental biology, lineage tracing is increasingly applied to stem cell research and in modeling cellular heterogeneity in cancer.
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