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Lineage tracing reveals Lgr5+ stem cell activity in mouse intestin…
https://www.narcis.nl/publication/RecordID/oai%3Apure.knaw.nl%3Apublications%2F63564826-71d2-4615-829e-76f3d0b03538#:~:text=Lineage%20tracing%20reveals%20Lgr5%2B%20stem%20cell%20activity%20in,%20%202012%20%2013%20more%20rows%20
Lineage tracing reveals Lgr5+ stem cell activity in mouse …
https://pubmed.ncbi.nlm.nih.gov/22855427/
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial. Studying mouse models, we provide direct, functional evidence for the presence of stem cell activity within primary intestinal adenomas, ….
Lineage Tracing Reveals Lgr5+ Stem Cell Activity in …
https://www.science.org/doi/10.1126/science.1224676
Moreover, the coexpressed Cre fusion protein can be activated at will in these stem cells by tamoxifen injection and will then recombine two …
Lineage Tracing Reveals Lgr5 Stem Cell Activity in …
https://www.science.org/doi/epdf/10.1126/science.1224676
Lineage Tracing Reveals Lgr5 Stem Cell Activity in Mouse Intestinal Adenomas tail) and the N terminus of cortical cytoskeleton- associatedproteinof~23kD(CAP23 20).Wealso assayed the kinase-associated 1 (KA1) domain from microtubule-associated protein –microtubule affinity–regulating kinase 1 (MARK1), which in-
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in …
https://www.jstor.org/stable/23268868
crossed into the Lgr5 knock-in mouse strain, ta moxifen injection can result in a visible change (e.g., a color) in an individual Lgr5 " cell that is inherited by all of its daughter cells. This strategy to document the behavior of stem cells is called lineage tracing. Although deletion of Ape in other cells of the intestinal epithelium does not lead to
Lineage Tracing Reveals Lgr5(+) Stem Cell Activity in …
https://www.researchgate.net/publication/230599679_Lineage_Tracing_Reveals_Lgr5_Stem_Cell_Activity_in_Mouse_Intestinal_Adenomas
By “lineage retracing” using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich …
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in …
https://ui.adsabs.harvard.edu/abs/2012Sci...337..730S/abstract
By “lineage retracing” using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat-containing heterotrimeric guanine nucleotide-binding protein-coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas.
Sci-Hub | Lineage Tracing Reveals Lgr5+ Stem Cell …
https://sci-hub.se/10.1126/science.1224676
Schepers, A. G., Snippert, H. J., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. (2012). Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas. Science, 337 (6095), 730–735. doi:10.1126/science.1224676 10.1126/science.1224676
Frontiers | Stem Cells, Hematopoiesis and Lineage …
https://www.frontiersin.org/articles/10.3389/fcell.2022.903528/full
FIGURE 1.HSC lineage tracing techniques in the mouse. (A) Transplantation-based approaches.Left: Transplantation of prospectively isolated candidate HSCs permits for assaying HSC activity at the single cell level. Here, all donor progeny in the mouse is derived from one cell. Right: Transplantation of ex vivo barcoded HSCs allows for monitoring the frequency of …
Lineage tracing reveals the phylodynamics, plasticity, and …
https://www.cell.com/cell/fulltext/S0092-8674(22)00462-7?rss=yes
Yang et al. developed a genetically engineered mouse model of lung cancer capable of continuous lineage tracing with single-cell RNA-seq readout. They identified the subclonal dynamics of tumors, gene modules underlying expansion, transient increases in cellular plasticity, stereotypical evolutionary paths to aggressiveness across tumor genotypes, and the spatial …
Lineage tracing reveals Lgr5+ stem cell activity in mouse …
https://core.ac.uk/display/85571073
By "lineage retracing" using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat-containing heterotrimeric guanine nucleotide-binding protein-coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas.
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