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Lineage tracing reveals Lgr5+ stem cell activity in mouse …
https://pubmed.ncbi.nlm.nih.gov/22855427/
By "lineage retracing" using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat-containing heterotrimeric guanine nucleotide-binding protein-coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas.
Lineage Tracing Reveals Lgr5+ Stem Cell Activity in …
https://www.science.org/doi/10.1126/science.1224676
By “lineage retracing” using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat–containing heterotrimeric guanine nucleotide–binding protein–coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas.
Lineage Tracing Reveals Lgr5 Stem Cell Activity in …
https://www.science.org/doi/epdf/10.1126/science.1224676
Lineage Tracing Reveals Lgr5 Stem Cell Activity in Mouse Intestinal Adenomas tail) and the N terminus of cortical cytoskeleton- associatedproteinof~23kD(CAP23 20).Wealso assayed the kinase-associated 1 (KA1) domain from microtubule-associated protein –microtubule affinity–regulating kinase 1 (MARK1), which in-
Lineage Tracing Reveals Lgr5⁺ Stem Cell Activity in …
https://pubag.nal.usda.gov/catalog/3007278
Lineage Tracing Reveals Lgr5⁺ Stem Cell Activity in Mouse Intestinal Adenomas Author: Schepers, Arnout G., Snippert, ... Subject: G-protein coupled receptors, color, mice, neoplasm cells, neoplasms, reporter genes, stem cells
[PDF] Lineage Tracing Reveals Lgr5+ Stem Cell Activity in …
https://www.semanticscholar.org/paper/Lineage-Tracing-Reveals-Lgr5%2B-Stem-Cell-Activity-in-Schepers-Snippert/7f9c9001df1a821e0fe9835ede2f873041426c80
This “lineage tracing” analysis suggests that tumor cells expressing the intestinal crypt stem cell marker Lgr5 (leucine-rich repeat containing G protein–coupled receptor 5) are the cells that fuel the growth of intestinal adenomas. Multicolor reporter genes signal the fate of stem cells that fuel the growth of intestinal tumors in mice.
Lineage tracing reveals Lgr5+ stem cell activity in mouse …
https://www.scienceopen.com/document?vid=571eabca-09e8-403b-a669-3e7e89371fc6
The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial. Studying mouse models, we provide direct, functional evidence for the presence of stem cell activity within primary intestinal adenomas, a precursor to intestinal cancer. By "lineage retracing" using the …
Lineage tracing reveals Lgr5+ stem cell activity in mouse …
https://www.mendeley.com/catalogue/f0bddcea-0d68-305f-b405-1c1c2863bce5/
By "lineage retracing" using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat-containing heterotrimeric guanine nucleotide - binding protein - coupled receptor 5) also marks a subpopulation of adenoma cells that fuel the growth of established intestinal adenomas.
Lineage Tracing Reveals Lgr5(+) Stem Cell Activity in …
https://www.researchgate.net/publication/230599679_Lineage_Tracing_Reveals_Lgr5_Stem_Cell_Activity_in_Mouse_Intestinal_Adenomas
By “lineage retracing” using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat–containing heterotrimeric guanine nucleotide–binding...
Summary of Lineage Tracing Reveals Lgr5+ Stem Cell …
https://prezi.com/gtcwwz5caxpw/summary-of-lineage-tracing-reveals-lgr5-stem-cell-activity-in-mouse-intestinal-adenomas/
Summary of Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas - Conclusion Using lineage retracing with Cre-reporter R25R-Confetti, this study was able to show that Lgr5, crypt stem cell marker, is used as a …
Lineage tracing reveals the phylodynamics, plasticity, and …
https://www.cell.com/cell/fulltext/S0092-8674(22)00462-7
Lineage tracing reveals cellular plasticity and evolutionary paths • Metastases are derived from spatially localized, expanding subclones of the tumor Summary Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations that enable uncontrolled growth and expansion to neighboring and distal tissues.
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