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The Elephant in the Lung: Integrating lineage-tracing, molecular ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434667/#:~:text=Early%20lung%20lineage%20labeling%20experiments%20took%20advantage%20of,type%20specific%20progenies%20%5B%2014%20%E2%80%93%2016%20%5D.
The elephant in the lung: Integrating lineage-tracing, …
https://pubmed.ncbi.nlm.nih.gov/32442602/
During lung development, the mesenchyme and epithelium are dependent on each other for instructive morphogenic cues that direct proliferation, cellular differentiation and organogenesis. Specification of epithelial and mesenchymal cell lineages occurs in parallel, forming cellular subtypes that guide the formation of both transitional developmental structures and the …
Lung Cancer’s Lineage Reveals How Tumors Grow
https://www.insideprecisionmedicine.com/topics/oncology/lung-cancers-lineage-reveals-how-tumors-grow/
They engineered mice such that when their lung cells were exposed to a tailor-made virus, that exposure activated a cancer-causing mutation in the Kras gene and deactivated tumor suppressing gene Trp53 in the cells, as well as activating the lineage tracing technology. The mouse model, developed in Jacks’ lab, was also engineered so that lung ...
The Elephant in the Lung: Integrating lineage-tracing, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434667/
Mesenchymal lineages and other classifications of activation. Early lung lineage labeling experiments took advantage of epithelial cell type specific reporter genes and demonstrated that proximal and distal lung epithelial lineages are specified before E10.5 [].Subsequent lineage tracing experiments identified proximal and distal progenitor cells and their cell type specific …
Lineage-negative Progenitors Mobilize to Regenerate …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312207/
Methods Injury (Influenza, Bleomycin) Treatment of animals with γ-secretase inhibitors Orthotopic lung transplantation Orthotopic tracheal transplantation Immunofluorescence analysis of tissue Quantification of lineage tracing Epithelial cell isolation and flow cytometry Orthotopic cell ...
Murine lung lipofibroblast lineage tracing - European …
https://erj.ersjournals.com/content/48/suppl_60/PA1815
Pulmonary diseases of the lung are characterized by a loss (chronic obstructive lung disease) or impaired formation (bronchopulmonary dysplasia) of the alveolar structure. New therapeutic concepts are urgently needed since therapeutic options are not available. Fibroblasts subtypes such as the lipofibroblasts (LFs), myofibroblasts (MFs) and PDGFRα+ fibroblasts, …
Cell tracing reveals the transdifferentiation fate of mouse …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406816/
Lineage-tracing studies with neutral and efficient labeling and gene reporting systems were performed to clarify whether EMT existed in pulmonary fibrosis. The results indicated that EMT contributes to the pathogenesis of pulmonary fibrosis, but it is not the major causative factor of this condition.
Deciphering cell lineage specification of human lung …
https://www.nature.com/articles/s41467-021-26770-2
Some of these mouse studies have utilized lineage tracing technologies, ... B. et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell …
Lineage Tracing Reveals the Dynamic Contribution of …
https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313715
Based on our lineage tracing and functional studies, we have provided definitive evidence that pulmonary pericytes are mobilized under certain conditions to muscularize distal pulmonary blood vessels . The demonstration that pulmonary pericytes are altered in patients with iPAH and overexpress CXCR-7 and TGF-βRII has relevance to our understanding of the …
Lung regeneration by multipotent stem cells residing at …
https://www.nature.com/articles/s41588-019-0346-6
Here we generated a dual lineage-tracing system by using Dre and Cre double recombinase 26,27 to fate-map CC10 + SPC + BASCs during lung maintenance and after bronchiolar or alveolar injuries. Our ...
Triple-cell lineage tracing by a dual reporter on a single …
https://pubmed.ncbi.nlm.nih.gov/31771978/
Genetic lineage tracing is widely used to study organ development and tissue regeneration. Multicolor reporters are a powerful platform for simultaneously tracking discrete cell populations. Here, combining Dre-rox and Cre-loxP systems, we generated a new dual-recombinase reporter system, called Rosa26 traffic light reporter ( R26-TLR ), to monitor red, green, and yellow …
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