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The complexities and caveats of lineage tracing in the mammary g…
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0774-5#:~:text=Lineage%20tracing%20is%20increasingly%20being%20utilised%20to%20probe,are%20important%20caveats%20associated%20with%20lineage%20tracing%20strategies.
Mammary lineage tracing: the coming of age - PubMed
https://pubmed.ncbi.nlm.nih.gov/25563489/
Mammary lineage tracing: the coming of age Abstract Identification and characterization of the normal epithelial lineages in the mammary gland is a fundamental step in understanding both development and cellular origin of cancer.
Mammary lineage tracing: the coming of age | SpringerLink
https://link.springer.com/article/10.1007/s00018-014-1817-7
Genetic lineage tracing (also called genetic fate mapping) is a critical tool for analysis of tissue development, homeostasis and cellular origin of cancer [ 26 ]. In situ lineage tracing The first in situ fate mapping in the mammary gland was done over a decade ago by the Smith laboratory [ 27 ].
Mammary lineage tracing: the coming of age.
https://www.ncbi.nlm.nih.gov/pubmed/25563489
Identification and characterization of the normal epithelial lineages in the mammary gland is a fundamental step in understanding both development and cellular origin of cancer. In contrast to other tissues where lineage tracing has been widely accepted as a method of choice for dissecting the stem cell
Lineage tracing of mammary epithelial cells using cell …
https://pubmed.ncbi.nlm.nih.gov/24936465/
Lineage tracing using Cre/lox transgenic mice provides a powerful tool for studying normal mammary epithelial cell (MEC) development and the cellular origins of mammary tumors under physiological settings. However, generation of new transgenic mice for lineage-tracing purposes is often time consuming.
Lineage Tracing of Mammary Stem and Progenitor Cells
https://pubmed.ncbi.nlm.nih.gov/27796960/
Lineage tracing analysis allows mammary epithelial cells to be tracked in their natural environment, thereby revealing cell fate and proliferation choices in the intact tissue. This technique is particularly informative for studying how stem cells build and maintain the mammary epithelium during development and pregnancy.
The complexities and caveats of lineage tracing in the …
https://pubmed.ncbi.nlm.nih.gov/27887631/
Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this technique is powerful for tracking cells in vivo and dissecting the roles of different cellular subsets in development, homeostasis and oncogenesis, there are important caveats associated with lineage tracing strategies.
The complexities and caveats of lineage tracing in the …
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0774-5
Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this technique is powerful for tracking cells in vivo and dissecting the roles of different cellular subsets in development, homeostasis and oncogenesis, there are important caveats associated with lineage tracing strategies.
Single-cell lineage tracing in the mammary gland reveals …
https://pubmed.ncbi.nlm.nih.gov/27779190/
Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny Abstract The mammary gland undergoes cycles of growth and regeneration throughout reproductive life, a process that requires mammary stem cells (MaSCs).
Single-cell lineage tracing in the mammary gland reveals …
https://www.nature.com/articles/ncomms13053/
Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny Felicity M. Davis , Bethan Lloyd-Lewis , Olivia B. Harris , …
The Theory and Practice of Lineage Tracing - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618107/
In the mammary epithelium, transplantation studies suggest the presence of multipotent stem cells that can give rise to both luminal and myoepithelial lineages, while genetic lineage-tracing studies suggest that these two populations are maintained by distinct populations of unipotent stem cells [ 24 ].
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