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Effects of spironolactone on heart rate variability and left ...
https://pubmed.ncbi.nlm.nih.gov/10980217/
Recent data show that blockade of aldosterone receptors by spironoloctone reduces the risk of morbidity and death among patients with severe heart failure. Heart failure secondary to ischemia is characterized by an imbalance of the autonomic nervous system, which can be assessed by analysis of the heart rate variability (HRV).
Spironolactone oral tablet: Dosage, side effects, uses, and more
https://www.medicalnewstoday.com/articles/drugs-spironolactone-oral-tablet
Mild side effects* of spironolactone oral tablets can include: nausea and vomiting diarrhea belly cramps leg cramps dizziness drowsiness headache confusion menstrual problems, such as irregular...
Efficacy and safety of spironolactone in the heart failure …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456096/
Compared with eplerenone and finerenone, spironolactone is the most wildly used MRAs. The active metabolite of spironolactone, canrenone has a relatively long serum half-life (10–35 h for the spironolactone vs. 4–6 h for eplerenone). Spironolactone is also the cheapest MRAs in the clinical practice. [ 19]
Race Influences the Safety and Efficacy of …
https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.113.000530
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