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Tracing the action of IL-2 in tolerance to islet-specific …
https://pubmed.ncbi.nlm.nih.gov/17372610/
Tracing the action of IL-2 in tolerance to islet-specific …
https://www.ncbi.nlm.nih.gov/pubmed/17372610
Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression to diabetes, and its action upon diabetogenic islet-specific CD4 T cells can be tracked. We find that IL-2 is not required for Aire-dependent thymic clonal deletion of high-avidity diabetogenic clones, but is essential for thymic formation of islet-specific Foxp3 …
Tracing the action of IL‐2 in tolerance to islet‐specific …
https://onlinelibrary.wiley.com/doi/abs/10.1038/sj.icb.7100049
We find that IL‐2 is not required for Aire ‐dependent thymic clonal deletion of high‐avidity diabetogenic clones, but is essential for thymic formation of islet‐specific Foxp3‐expressing CD4 T cells. The absence of IL‐2 results in the expansion of low‐avidity Foxp3 − …
Tracing the action of IL‐2 in tolerance to islet‐specific …
https://onlinelibrary.wiley.com/doi/full/10.1038/sj.icb.7100049
The mechanism by which IL‐2 prevents diabetes is therefore through the establishment of a repertoire of islet‐reactive Foxp3 + T cells within the thymus, and limitation of the peripheral activation of low‐avidity islet‐reactive T cells …
Tracing the action of IL-2 in tolerance to islet-specific …
https://www.researchgate.net/publication/6433987_Tracing_the_action_of_IL-2_in_tolerance_to_islet-specific_antigen
Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression to diabetes, and its action upon diabetogenic islet …
Tracing the action of IL‐2 in tolerance to islet‐specific …
https://www.semanticscholar.org/paper/Tracing-the-action-of-IL%E2%80%902-in-tolerance-to-antigen-Liston-Siggs/77efb8c8b1420f58e74b10b0d81778f01f308551
The mechanism by which IL‐2 prevents diabetes is through the establishment of a repertoire of islet‐reactive Foxp3+ T cells within the thymus, and limitation of the peripheral activation of low‐avidity islet-reactive T cells that normally escape thymic negative selection. Genetic variants of interleukin 2 (IL‐2) and its receptor are associated with murine and human susceptibility to ...
Tracing the action of IL-2 in tolerance to islet-specific …
https://vivo.scripps.edu/display/e2n318679
Tracing the action of IL-2 in tolerance to islet-specific antigen ... Immune Tolerance; Interleukin-2; Islets of Langerhans; Lymphocyte Activation; Mice; Mice, Transgenic; Thymus Gland; Research. keywords . Foxp3 autoimmune diseases immune tolerance interleukin 2 regulatory T cells Identity. International Standard Serial Number (ISSN) ...
Tracing the action of IL-2 in tolerance to islet-specific …
https://ora.ox.ac.uk/objects/uuid:a2e656c5-6cbc-440c-9f48-62ce7d3bc45a
Tracing the action of IL-2 in tolerance to islet-specific antigen. Abstract: Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown.
Tracing the action of IL-2 in tolerance to islet …
https://core.ac.uk/download/pdf/34460654.pdf
Tracing the action of IL-2 in tolerance to islet-specific antigen Adrian Liston, Owen M Siggs and Christopher C Goodnow Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown.
Tracing the action of IL-2 in tolerance to islet-specific …
https://core.ac.uk/display/34460654
Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression to diabetes, and its action upon diabetogenic islet- specific CD4 T cells can be tracked. We find that IL-2 is not required for Aire-dependent thymic clonal deletion of high-avidity diabetogenic clones, but is essential for thymic formation of islet- specific Foxp3-expressing …
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