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Monosynaptic Restriction of Transsynaptic Tracing from ...
https://www.sciencedirect.com/science/article/pii/S0896627307000785#:~:text=Transcomplemented%20Transsynaptic%20Tracing%20%28A%29%20A%20deletion%20mutant%20tracing,be%20restricted%20to%20the%20neuronal%20population%20of%20
Transsynaptic Tracing from Peripheral Targets with …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692604/
Transsynaptic tracing has become a powerful tool used to analyze central efferents that regulate peripheral targets through multi-synaptic circuits. This approach has been most extensively used in the rodent brain by utilizing the swine pathogen pseudorabies virus (PRV), especially the attenuated strain PRV-Bartha first described in 1961 12.
Transsynaptic tracing and its emerging use to assess …
https://pubmed.ncbi.nlm.nih.gov/32101353/
Transsynaptic tracing and its emerging use to assess graft-reconstructed neural circuits Fetal neural progenitor grafts have been evaluated in preclinical animal models of spinal cord injury and Parkinson's disease for decades, but the initial reliance on primary tissue as a cell source limited the scale of their clinical translatability.
Transsynaptic Tracing from Peripheral Targets with …
https://pubmed.ncbi.nlm.nih.gov/26436639/
Transsynaptic tracing has become a powerful tool used to analyze central efferents that regulate peripheral targets through multi-synaptic circuits. This approach has been most extensively used in the brain by utilizing the swine pathogen pseudorabies virus (PRV) (1).
Transsynaptic tracing and its emerging use to assess …
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3166
The utility of transsynaptic viral tracing was first demonstrated with the use of herpes simplex viruses (HSVs) and unmodified rabies viruses …
Anterograde or Retrograde Transsynaptic Circuit Tracing …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776322/
Viruses have been used as transsynaptic tracers, allowing one to map the inputs and outputs of neuronal populations, due to their ability to replicate in neurons and transmit in vivo only across synaptically connected cells. To date, their use has been largely restricted to mammals.
Transsynaptic Tracing with Vesicular Stomatitis Virus …
https://www.ncbi.nlm.nih.gov/sites/ppmc/articles/PMC3711516/
The use of neurotropic viruses as transsynaptic tracers was first described in the 1960s, but only recently have such viruses gained popularity as a method for labeling neural circuits. The development of retrograde monosynaptic tracing vectors has enabled visualization of the presynaptic sources onto defined sets of postsynaptic neurons.
Monosynaptic restriction of transsynaptic tracing from …
https://pubmed.ncbi.nlm.nih.gov/17329205/
The best available tools, transsynaptic tracers, are unable to distinguish weak direct connections from strong indirect ones. Furthermore, no tracer has proven potent enough to label any connected neurons whatsoever when starting from a single cell.
Anterograde or retrograde transsynaptic labeling of CNS …
https://pubmed.ncbi.nlm.nih.gov/21825165/
Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors Abstract To understand how the nervous system processes information, a map of the connections among neurons would be of great benefit. Here we describe the use of vesicular stomatitis virus (VSV) for tracing neuronal connections in vivo.
Neurotropic virus tracing suggests a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162419/
In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions. J. Comp.
Genetic Transsynaptic Techniques for Mapping Neural …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524129/
(1) A genetic transsynaptic tool often includes five components: an engineered receptor, an engineered ligand, a protease, a transcription factor (TF), and a reporter. (2) When a genetic transsynaptic tool is applied, a driver line for neurons of interest drives the expression of the engineered ligand.
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